Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B.
نویسندگان
چکیده
To study drug-receptor interactions, new thio-derivatives of salvinorin A, an extremely potent natural kappa-opioid receptor (KOR) agonist, were synthesized. Obtained compounds were examined for receptor binding affinity. Analogs with the same configuration at carbon atom C-2 as in natural salvinorin A showed higher affinity to KOR than their corresponding epimers.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 17 8 شماره
صفحات -
تاریخ انتشار 2007